The plot of Open Your Mind follows the extraterrestrial origin of life, coming from outerspace as six deities (Intermission act), evolving into water (Sho-ho) then emerging to the air (Hyakkin) and to the ground (Ku-nu). Each one of these creatures rules one of the six elements of the godai philosophy, i.e. Earth, Water, Fire, Wind (referred to as kaze in the Hyakkin chant), Sky and Consciousness (referred to as "Awakening" in the movie's title).

Following the popularity of the original omnibus OVA, this release offers 4 more stories but in animation only.

Naoko-san is an alien from the planet Yuri, who is plotting to conquer the Earth by yurifying it. Misuzu is a junior high girl and is always troubled by Naoko-san, who lives on the roof of her house.

10,000 years in the future, the world has become a very different place; monsters roam the land freely, and people, although equipped with high tech weapons and cybernetic horses, live a humble life more suited to centuries past. The story focuses on a small hamlet plagued by monster attacks and living under the shadow of rule by Count Magnus Lee, a powerful vampire lord who has ruled the land for thousands of years. When a young girl is bitten by the Count and chosen as his current plaything, she seeks out help of a quiet wandering stranger, D. It so happens that D is one of the world's best vampire hunters, and he takes it upon himself to cut through Magnus Lee's many minions, and put an end to the Count's rule.