Each episode follows Fukuzou Moguro, a traveling salesman, and his current customer. Moguro deals in things that give his customers their heart's desire, and once his deals are made and their unhealthy desires are satisfied, Moguro's customers are often left with terrible repercussions, especially if they break the rules of his deals...

In Hokkaido, it is rumored that there is a stash of hidden gold. This gold was supposedly stolen by a man who killed the original Ainu owners; and before being captured and imprisoned by the police, he hid it in a secret location. In order to relay the gold's location to his comrades on the outside, he tattooed the map on the bodies of his cellmates and promised them a share of the gold—provided they managed to escape and find it. In Golden Kamuy 2nd Season, First Lieutenant Tokushirou Tsurumi plans to give the 7th Division an advantage in the war for the tattoos by getting a taxidermist to create skins that only he can distinguish as fake. Meanwhile, Saichi "The Immortal" Sugimoto, Asirpa, and their companions continue their hunt for the skins by following a strange rumor: a thief who broke into a home in Yubari found taxidermied human corpses, among which was a torso with strange tattoos. [Written by MAL Rewrite]

In early 1900s Hokkaido after the Russo-Japanese war, Saichi Sugimoto tirelessly pans for gold. Nicknamed "Sugimoto the Immortal" for his death-defying acts in battle, the ex-soldier seeks fortune in order to fulfill a promise made to his best friend before he was killed in action: to support his family, especially his widow who needs treatment overseas for her deteriorating eyesight. One day, a drunken companion tells Sugimoto the tale of a man who murdered a group of Ainu and stole a fortune in gold. Before his arrest by the police, he hid the gold somewhere in Hokkaido. The only clue to its location is the coded map he tattooed on the bodies of his cellmates in exchange for a share of the treasure, should they manage to escape and find it. Sugimoto does not think much of the tale until he discovers the drunken man’s corpse bearing the same tattoos described in the story. But before he can collect his thoughts, a grizzly bear—the cause of the man's demise—approaches Sugimoto, intent on finishing her meal. He is saved by a young Ainu girl named Asirpa, whose father happened to be one of the murdered Ainu. With Asirpa's hunting skills and Sugimoto's survival instincts, the pair agree to join forces and find the hidden treasure—one to get back what was rightfully her people's, and the other to fulfill his friend's dying wish. [Written by MAL Rewrite]

A young man named Akitsu Masato is captured by a secret govt. project known as "Last Guardian". He is told that his life as a normal student was all a lie, and that his real destiny is to be the pilot of a great robot called "Zeorymer of the Heavens". The truth of this is hammered in when Masato sees his parents accept payment for raising him. The Last Guardian is preparing for the resurrection of "Hau Dragon", an organization bent on world conquest. 15 years ago, Hau Dragon built 8 great robots. Each of the mecha represents a force of nature. However, before any of the robots could be used, their creater Kihara Masaki destroyed the robots except for the leader: Zeorymer. He took Zeorymer and an embryo to the government. The embryo became the boy Masato. Now, Hau Dragon has rebuilt the other 7 mecha and wants the 8th. It will be up to Masato and Himuro to pilot Zeorymer and fight against the Hau Dragon, but neither Masato or Himuro are all that they seem. (Source: AniDB)