Juna Ariyoshi is an ordinary Japanese schoolgirl, who possesses a childlike curiosity and a strong admiration toward nature. One day, while on a trip with her boyfriend, Tokio Oshima, Juna dies from a motorcycle accident. However, she is given a chance to live by an individual named Chris Hawken. He offers her powers that make her the avatar of time; in exchange, she must fight to protect the Earth from evil forces called raaja, which are born out of the toxic pollution human beings have caused. She soon discovers that this is no easy task. While trying to master her newfound powers, she must also seek answers to deep questions about the ways science and technology have taken away humans' primal and instinctive connections with nature. With the help of Chris, his assistant Cindy Klein, and a powerful international organization named SEED, it is up to Juna to overcome her fears and find a way to stop the raaja from destroying everyone and everything she cares for. [Written by MAL Rewrite]

Unaired episode included with the Blu-ray box set.

In the year 2010 AD, Hyper Hurricanes born concurrently all over the world caused severe damage. Five billion people lost their lives, decreasing the world's population to 3 billion. Existing economies and military were wiped out. Countries were frozen under solid ice, plains sank beneath seas, the world was changed dramatically. Human civilization enters a chaotic era. Poverty flourished outside of these economic zones and slums were widespread. The ruling class called themselves Logos and maintained their position by force of arms. They call the poor Revenus, who are exiled to live outside the special economic areas. Time has passed since then. Katsuragi Jo and Tsurasawa Jin, escape from Phantom, a force organized to watch Revenus and to suppress renegade elements of the Logos, taking with them a mysterious girl, Nobuto Sana. There are many who are interested in her, all with their own reasons.

A special animated commercial to celebrate the release of the manga's fifth volume. The full length version of the commercial was released on Kodansha's official YouTube channel the day after the short version was released on TV. It features the anthropomorphized cells of a human body, with the protagonist being a red blood cell named AE-3803.