In the beginning, an "orb" is cast unto Earth. "It" can do two things: change into the form of the thing that stimulates "it"; and come back to life after death. "It" morphs from orb to rock, then to wolf, and finally to boy, but roams about like a newborn who knows nothing. As a boy, "it" becomes Fushi. Through encounters with human kindness, Fushi not only gains survival skills but grows as a "person". But his journey is darkened by the inexplicable and destructive enemy Nokker and cruel partings with the people he loves.

Let's walk and talk. Can you get up? The Gnosia lie. Pretending to be human, they'll get in close, trick and deceive, and then eradicate each person in the vicinity from the universe, one victim at a time. The crew of a drifting spaceship, facing off against a mysterious and deadly threat known as the "Gnosia" and having no idea who among them is really the enemy, formulate a desperate plan for survival. The most suspicious among them will be put into "cold sleep" one by one, in an effort to completely rid the ship of Gnosia. However, it is almost impossible to tell whether each person put into cold sleep was really Gnosia—or simply a poor, unfortunate scapegoat, sacrificed by the Gnosia for their own survival. Can the humans emerge victorious? Or is mankind doomed...?

Tokyo is the home of national-level horse girls and the next generation of running prodigies. Jou Kitahara, a rookie trainer with big dreams and modest expectations, does not expect to find talent in the quiet town of Kasamatsu—until he meets an ash-gray-haired girl with a wild, unconventional stride. As a child with bad knees, Oguri Cap spent much of her early life in pain, struggling to stand. But through relentless perseverance, she overcame her limits and found liberation in the very thing that once seemed impossible: running. While the other horse girls at Kasamatsu chase victory and fame, Oguri runs without ambition, driven only by the joy of movement. Fujimasa March, a rising regional star, commands attention with her discipline, talent, and tenacity. For her, running is a matter of pride. But when a school-organized race brings her face-to-face with Oguri's raw, unpolished stride, March's confidence begins to waver. In turn, something in Oguri shifts after racing March. For the first time, a spark of ambition ignites within her—a desire to win that will take her beyond the confines of her hometown to the grand stages waiting on the horizon.

Living in the slums of a wealthy town, Rudo and his foster father Regto try to coexist with the rest of the town's residents, but Rudo despises the wastefulness of the upper class. Ignoring the warnings from those around him, Rudo regularly rummages through the town's garbage in search of anything useful or valuable to save from the "Abyss"—a massive hole where anything considered trash is dumped, including people. Rudo's biological father was one such person, having been thrown into the Abyss after he was accused of murder. One day, after running into a mysterious figure on the way home, Rudo returns to find Regto's dying body on the floor. He is immediately found at the scene by the authorities and is charged with murder. No one believes his claims of innocence, and he is thrown into the Abyss. Instead of dying, however, he finds himself in a strange, foul-smelling place surrounded by monsters made out of trash. When Rudo is attacked by said monsters, he is saved by a man named Enjin, who reveals himself to be a "Cleaner"—someone who uses special weapons called Vital Instruments to combat these creatures. In order to get his revenge on the one who killed Regto, Rudo reluctantly becomes a Cleaner to fight his way back up and out of the Abyss.