Lecherous high school boy Hanappe is visited by two demons who step from his TV and immediately fall in lust with his mother and sister. The demons turn Hanappe's home into a meeting ground for their demonic friends and grant Hanappe the power of the Hanappe Bazooka. Now his index finger is capable of both a deadly blast and the ability to drive women in a lustful frenzy, but Hanappe isn't very good at controlling it and winds up in serious trouble.

Hideo Ozu is an editor in a shady adult video company. For years, he has dreamed of being a motion picture director while his childhood friend Mai Kurosawa has become an upcoming actress. Then one day, his dreams are shattered when Mai takes all of his amateur videos of her and tells him to get out of her life. On his way home after a few drinks, Hideo bumps into Cyberdoll Sara, who makes him mark an invoice. When he arrives at his pad, Hideo is greeted by three Cyberdolls - Mai, Ai and Mie. All three of them happen to look like different age variations of Mai Kurosawa. And when Kurosawa announces the release of a biography video of her using Hideo's old footage, Hideo decides to start his directing dreams over again using his three Cyberdolls.

Saito Hiraga and Louise Françoise Le Blanc de La Vallière go on the offensive after the events of Zero no Tsukaima: Princesses no Rondo. Together, they face off against King Joseph in the Holy City of Romalia with the help of two others who control the power of the “void”. But in the midst of the many conflicts ahead of them, an ancient evil begins to stir in the shadows. Will their close bonds blossom into something more or will they be shattered through the ever increasing difficulty of the tasks that they must undertake? Zero no Tsukaima F follows the story of Louise and Saito as they face their final challenges together.

Despite having a good reputation as one of the most seasoned guards in the local guild of Mebuki, Kikuru Madan believes he has been wasting his youth and hopes to spend the rest of it like any other person. However, his conscience prevents him from retiring at present, as he worries about the guild's future without him. Coincidentally—as if to help him find his successor—the guild's receptionist, Enome, assigns Kikuru four fresh recruits: the energetic beastwoman Hitamu "Hitamuki" Kyan, the prodigy Maidena Ange, the laid-back Toxico Dannar, and the stalwart Hanabata Nohkins. Although each of them possesses significant talents, they also display characteristics that detract from their potential—including Hitamu's extreme clumsiness and Hanabata's unintentional perverseness. As if there was not enough to deal with, the monsters outside Mebuki's walls start exhibiting odd behavior by targeting women salaciously, causing the party endless problems in more ways than one. Nevertheless, Kikuru is committed to retiring early; to achieve his goal, the guidance he gives the trainees will be absolutely essential.