Another version of Miracle Train: Chuo-sen e Youkoso. The first version of the Miracle Train project focused on the stations of the central Chuo line, while the new anime and related stories deal with the Oedo subway line. As a result, the anime will feature a newer cast of characters—specifically, Fumi Roppongi, Rintarou Shinjuku, Izayoi Tsukishima, Iku Shiodome, Saki Tochou, and Itsumi Ryougoku.

The "Medicine Seller" is a deadly and mysterious master of the occult who travels across feudal Japan in search of malevolent spirits called "mononoke" to slay. When he locates one of these spirits, he cannot simply kill it; he must first learn its Form, its Truth, and its Reason in order to wield the mighty Exorcism Sword and fight against it. He must begin his strange exorcisms with intense psychological analysis and careful investigative work—an extremely dangerous step, as he must first confront and learn about the mononoke before he even has the means to defeat it. The Medicine Seller's journey leads him to an old-fashioned inn where Shino, a pregnant woman, has finally found a place to rest. The owner has reluctantly placed her in the last vacant room; however, as she settles in, it quickly becomes clear that the room is infested by a lethal band of mononoke, the Zashiki Warashi. With his hunter's intuition, the Medicine Seller begins his investigation to discover the Form, the Truth, and the Reason before the Zashiki Warashi can kill again. [Written by MAL Rewrite]

After years of conflict, humans and monsters have settled their differences and are now at peace. This post-war era led to the foundation of Lindworm—a town which has since become the focal point of racial harmony. As a human doctor specializing in monster biology, Glenn Litbeit runs a small clinic alongside his partner, Saphentite Neikes, who is a half-snake monster known as a lamia. He uses his knowledge to tend to any monsters who seek his aid. Whatever affliction, concern, or injury it may be, he will always be there, ready to help. [Written by MAL Rewrite]

With his parents abroad, Kimihito Kurusu lived a quiet, unremarkable life alone until monster girls came crowding in! This alternate reality presents cutting-edge Japan, the first country to promote the integration of non-human species into society. After the incompetence of interspecies exchange coordinator Agent Smith leaves Kimihito as the homestay caretaker of a Lamia named Miia, the newly-minted "Darling" quickly attracts girls of various breeds, resulting in an ever-growing harem flush with eroticism and attraction. Unfortunately for him and the ladies, sexual interactions between species is forbidden by the Interspecies Exchange Act! The only loophole is through an experimental marriage provision. Kimihito's life becomes fraught with an abundance of creature-specific caveats and sensitive interspecies law as the passionate, affectionate, and lusty women hound his every move, seeking his romantic and sexual affections. With new species often appearing and events materializing out of thin air, where Kimihito and his harem go is anyone's guess! [Written by MAL Rewrite]