The signing of a peace treaty has secured a tenuous ceasefire between mankind and the Zex, beings who emerged from space/time rifts connected to mysterious, distant worlds. Partnered with a Zex named Rigel, Azumi Kakamigahara must shoulder the fate of her own idyllic world. The unlikely pair head to newly established Fujimisaki Academy, where their destinies await.

Midori Asakusa sees the world a bit differently. Always having her nose in a sketchbook, Asakusa draws detailed landscapes and backgrounds of both the world around her and the one within her boundless imagination. Even the simple act of doodling on a wall evolves into an emergency repair on the outer hull of her spaceship. She is only brought back to reality by her best friend Sayaka Kanamori. The pair are stark opposites, with Asakusa's childlike wonder contrasted by Kanamori's calculated approach to life. After a chance encounter where the two "save" the young model Tsubame Misuzaki from her overprotective bodyguard, a connection instantly sparks between Asakusa and Misuzaki, as both share an intense passion for art and animation. Whereas Asakusa is interested in backgrounds and settings, Misuzaki loves drawing the human form. Sensing a money-making opportunity, Kanamori suggests that they start an animation club, which they disguise as a motion picture club since the school already has an anime club. Thus begins the trio's journey of producing animation that will awe the world. From the brilliant mind of Masaaki Yuasa, Eizouken ni wa Te wo Dasu na! is a love letter to animation, wildly creative in its approach, and a testament to the potential of the medium.

Hirono Kenta is your average geeky junior high school student. His childhood obsession has always been Tokusatsu and anime. In fact, he fancies himself as a "Hero of Justice" and often is seen running around in a makeshift costume of his own design called "Wing Man." Most of his fellow classmates thinks he's just a crazy otaku, but his childhood friend Ogawa Miku thinks he's a noble spirit. One day as Hirono is walking to school, a beautiful and voluptuous girlliterally drops out of the sky and into his life. Hirono, bewildered by the event, none-the-less takes the girl to his home to recuperate (this is his duty as a "Hero of Justice"). He also keeps the "Dream Note" so that he can transpose his favorite "Wing Man" costume designs into it. Later, Hirono is confronted by the girl who reveals herself to be Yume Aoi, Princess of the Dreamscape called Botoreem. Her domain has been conquered by the power mad despot, Rimeru and his armies of monstrous "Seed Men." She barely escaped her domain with the power artifact known as the "Dream Note." The "Dream Note" enables its possessor to create anything they desire by merely drawing or writing information within its pages. Rimeru seeks to steal it to become Master of the Universe. She demands that Hirono give her back the book, but Hirono had already begun drawing into the book (mystically linking himself to it). Hirono soon discovers that his designs and notes on Wing Man become reality and he in turn becomes his own creation. Using these powers and abilities, he and Aoi begin their strange and amazing adventure. Along the way, Hirono inadvertently involves all of his friends, especially Miku in his quest to help Aoi free her people and save her father. Rimeru sends his various minions to Earth's dimension to retrieve the book. One his henchmen is the noble yet devious Kitakura who goes as far as infiltrating Hirono's junior high school masquerading as a teacher.

Hiyori Suzumi, who left her hometown to continue pursuing her passion of track and field, enrolls in Tokyo's Sakuragaoka High School. In searching for a part-time job, Hiyori ends up becoming an apprentice manager for her classmates Yuujirou Someya and Aizou Shibasaki, who are members of the idol group LIPxLIP. The story follows the struggles that Hiyori faces with school, extracurricular activities, and her managing job, as well as the idol group LIPxLIP as they perform on stage.