The gang is traveling along when they find a girl in need. Of course, they all can't resist going after her. This girl isn't all that she seems... her motive or her "humanity".... and soon the whole gang has Sanzo's past on their hands and one certain young boy who can keep a grudge for decades...

My-Otome Zwei takes place one year after the events of My-Otome. Arika is now a full-fledged Otome (though still under the tutelage of Miss Maria) and Nagi is incarcerated in a prison somewhere in Aries. The various nations are at peace with one another and plan to hold S.O.L.T. (Strategic Otome Limitation Talks) to discuss limiting the numbers of Otome. A mission to destroy a meteor threatening to collide with Earl sets into motion a chain of events which result in a mysterious shadowy figure attacking Garderobe and several Otome as well as a new, more powerful version of Slave appearing across the planet. To make matters worse, Queen Mashiro disappears following an argument with Arika. The series follows Arika's search for Mashiro as well as Garderobe's attempts to uncover the truth behind the shadowy figure.

Destiny or delusion? It's a hilarious rollercoaster of laughter and confusion when Taishi, the ultimate otaku, drags his friend Kazuki into the swirling world of ambition, hatred, and love—the world of fan comics! Poor clueless Kazuki must sink or swim when he's dumped straight into the middle of a massive comic convention. Lost amidst hoards of buyers, sellers, and cosplayers, Kazuki is about to be baptized by fire, all in order to lead him toward his true calling: to take over the world through fan comics! Meanwhile, Kazuki's childhood friend Mizuki isn't about to let him be dragged from his normal life without a fight! But will she be able to stop the addictive draw of the new world that lies before Kazuki? Little by little, Kazuki is slipping down the path towards destiny—and Taishi is shoving him every step of the way!

Peace has been brought to both earths, and everyone is living out their lives as normal citizens. But how normal could life be for war hero Kazuki living with five beautiful women under the same roof... Apparently, he doesn't need to wait long to find out. An ancient artifact that is the key to their adventures in the parallel universes forces Kazuki to hop in the saddle yet again, but this time it's outer space or bust. (Source: ANN)