Nihility is the world's greatest catastrophe. Humans can only unite their allies against "blessers", monsters from the world of nihility. Shazhou, the continental border, becomes an important line of defense against invaders. A dark force called "Shadow of Blessing" is looking for the power that has been sealed. Dark Island, the leading state of the human alliance, sends White Wolf Yujia to destroy the dark force. But a mysterious girl called Coral from the world of nihility causes a storm in Shazhou. The red thread of fate connects everyone holding the belief of uncovering the historical truth hidden in nihility. The girl is fighting against her fate beyond her belief, and a romantic legend officially begins.

The story centers around an illness-stricken, constantly bullied orphan girl named Minori. After one rainy day, she doesn't turn up at school, having been admitted into a hospital in a distant town. Two months pass, and the girl's two school friends, Takashi and Kyouko, receive a mysterious email with no sender listed. The email reveals a summer festival taking place at a nearby town...

In 356 BC, Alexander the Great arrives in Greece with the ominous destiny that he will become the "destroyer of the world." Inheriting the crown, he becomes king of the Macedonians and starts down a road of conquest with terrific speed. Alexander ultimately confronts his fated nemesis, Darius the Third, in a war with Persia which changes Alexander into the devil he was fated to become, assuring the destruction of all in his path, and possibly himself.

Haruka Nishikikoji is an overweight doctor that never seems to attract any girls. Fate finds a way as he lands a job as a doctor in an elementary school, wherein his workplace can be found on top of the schools' roof and the actual clinic looks like a medieval castle. Just when everything seems to go downhill, a surprise came one day, her first love Koizumi Miyuki, applies as her soon to be nurse.