Years ago, humanity almost got wiped out by huge magical armored insects that had become too strong and aggressive to handle. Because of these giant bugs, humans do not live on the earth anymore, but in floating cities instead. However, this does not mean that everything is lost, because the wizards from prestigious floating wizard academies are fighting these monsters. Kanata Age is a young man now labelled as a traitor even though he was once praised as the "Black Master Swordsman." He gets a chance to repair his reputation by instructing the team E601, which seems to be facing some difficulties. It consists of three girls, Misora Whitale, Lecty Eisenach, and Rico Flamel, each with problems of their own. It appears that Kanata will get in deep waters more than once because of them...

When a shapeshifting demon with a thirst for human flesh, known as "youma," arrives in Raki's village, a lone woman with silver eyes walks into town with only a sword upon her back. She is a "Claymore," a being manufactured as half-human and half-youma, for the express purpose of exterminating these monsters. After Raki's family is killed, the Claymore saves his life, but he is subsequently banished from his home. With nowhere else to go, Raki finds the Claymore, known as Clare, and decides to follow her on her journeys. As the pair travel from town to town, defeating youma along the way, more about Clare's organization and her fellow warriors comes to light. With every town cleansed and every demon destroyed, they come closer to the youma on which Clare has sought vengeance ever since she chose to become a Claymore. [Written by MAL Rewrite]

"Mushi": the most basic forms of life in the world. They exist without any goals or purposes aside from simply "being." They are beyond the shackles of the words "good" and "evil." Mushi can exist in countless forms and are capable of mimicking things from the natural world such as plants, diseases, and even phenomena like rainbows. This is, however, just a vague definition of these entities that inhabit the vibrant world of Mushishi, as to even call them a form of life would be an oversimplification. Detailed information on Mushi is scarce because the majority of humans are unaware of their existence. So what are Mushi and why do they exist? This is the question that a "Mushishi," Ginko, ponders constantly. Mushishi are those who research Mushi in hopes of understanding their place in the world's hierarchy of life. Ginko chases rumors of occurrences that could be tied to Mushi, all for the sake of finding an answer. It could, after all, lead to the meaning of life itself. [Written by MAL Rewrite]

The student-filled Academy City is at the forefront of scientific advancement and home to the esper development program. The seven "Level 5" espers are the most powerful in Academy City, and ranked third among them is middle schooler Mikoto Misaka, an electricity manipulator known as "The Railgun." When strange incidents begin occurring throughout the city, she finds each crime to be connected to the elusive "Level Upper," a legendary device that allegedly increases the esper level of its user. As the situation escalates, it becomes apparent that there is more to the Level Upper than meets the eye, and that Academy City may be a far more twisted place than the glamorous utopia it appears to be. Toaru Kagaku no Railgun focuses on Mikoto and her friends—and the dangerous situations they find themselves in—as they get caught up in the matter of the Level Upper. As Mikoto says, "There's never a dull moment in this city."