An artificial island in Tokyo Bay—Kyokutou Houreigai Tokubetsu Chiku (Far East Special District), commonly known as the 24-ku (24th Ward). Childhood friends Ran, Kouki, and Shuuta, who were born and raised there, have different family backgrounds, hobbies, and personalities, but always hung out together. However, their relationship changes drastically in the wake of a certain incident. At the first anniversary memorial of the incident, the three friends happen to meet again and their phones begin to ring simultaneously. The phone call is from a supposedly dead friend, urging them to "choose the future." The three will try to protect their beloved 24th Ward and the future of its people in their own ways.

Kyon, your typical high school student, has long given up his belief in the supernatural. However, upon meeting Haruhi Suzumiya, he quickly finds out that it is the supernatural that she is interested in—aliens, time travelers, and espers among other things. When Haruhi laments about the lack of intriguing clubs around school, Kyon inspires Haruhi to form her own club. As a result, the SOS Brigade is formed, a club which specializes in all that is the supernatural. Much to his chagrin, Kyon, along with the silent bookworm, Yuki Nagato, the shy and timid Mikuru Asahina, and the perpetually smiling Itsuki Koizumi, are recruited as members. The story follows the crazy adventures that these four endure under their whimsical leader, Haruhi. The story is based on the light novels by Nagaru Tanigawa. [Written by MAL Rewrite]

Kazunari Usa is a high school freshman who will start living alone due to his parents now working in a different area. Excited for his new independent life, he hopes to go about his teenage days without the worry of dealing with any strange people, but as he soon discovers, his new boarding house Kawai Complex is far from ordinary. The various tenants at Kawai Complex are all quite eccentric characters. Shirosaki, Kazunari's roommate, is a pervert and masochist; Mayumi Nishikino, a borderline alcoholic office lady, hates couples because of her unfortunate luck with men; and Sayaka Watanabe, a seemingly innocent college student, enjoys leading men on. Shocked with the lack of decent individuals at his new residence, Kazunari is about to leave when he runs into shy senior student Ritsu Kawai and finds himself slowly falling in love with her. [Written by MAL Rewrite]

Yui Komori, still held captive by the Sakamaki brothers—pureblood vampires after her blood—experiences yet more bizarre twists to her life following her stay at their household. Though haunted by enigmatic dreams, Yui soon deciphers their meaning when caught in a car crash, which subsequently leads to meeting four new vampires: the Mukami brothers, Ruki, Azusa, Kou, and Yuuma, who themselves capture the bewildered girl. Yui later awakens in the Mukami mansion, where the brothers reveal their plans for her: she is their "Eve," and her blood will find the "Adam" among them; together, they will have the power to rule the world. However, with the Sakamaki brothers hot on their heels, things might not go quite as smoothly as they had imagined.