After a meteor hits Earth, traitor forces have (for all intents and purposes) taken over, and the people are suffering. In the chaos, a boy named Tetsuro Daiba, who had lost his parents in the meteor hit, is paid a visit by Mello, a mysterious woman appearing in a bright light. When Daiba comes to, he finds himself in a spaceship infirmary under observation. Stealing a fighter that he didn't know how to pilot (until he tried it), he breaks out, flying like a total pro. He was able to remember how to pilot from his DNA memory... and to find out more, his doctor friend takes him to his secret underground lab, in which he acts as a professor to find out ways to stop the traitor regime. When the forces invade to take him back, a girl named Rei Yuuki mysteriously shoots down their entire carrier with only a fighter jet! Apparently, both have mysterious powers that the enemies want, which may or may not be connected to their being the only two known survivors of the meteor impact. While looking for a third survivor (which turned out to be a cat), the two are taken by force to Queen Photon (ruler of the traitor regime), who claims that she is out to SAVE the Earth from those who sent the Meteor. The two don't know whether to believe her or Mello until the (telepathic) cat breaks them out of the Queen's sealed chamber, and Mello comes to straighten things out. That's when the two (er, three) of them make a choice... Stay on a planet that can't support their advanced race, or strike out into the unknown of space?

The story circulates around a mysterious and dangerous island referred to simply as "G". A long time ago, a powerful god named Gestalt was banished to the earth and he had found refuge in the island known as G. To utter the name for which it stands is forbidden, for people were so afraid of the wrath of the god that they considered his name a curse. Father Oliver is a priest who has left his order and traveled to the island of G in order to discover the truth behind it. He ends up making the acquaintance of a young girl named Ohri, who turns out to be quite adept in magic. Meanwhile, the head of the order has hired a dark elf named, Suzu, to track down Oliver and bring him back. Suzu finds him easily enough. However, she hadn't anticipated the powerful sorceress in his company, Ohri. The girl disposes of Suzu for the moment, and she and the Father continue on. As if things weren't rough enough, the island of G has it's share of monsters and magic-users to get in the way of their travels.

To the unsuspecting eye Maki, Reimi and Yuka may not look like ace crime fighters, which might explain why they're stuck on traffic patrol instead of more "exciting" police duties. All that changes when Yuka gets herself kidnapped by a white slave organization run by a politically connected businessman who's got the rest of the police cowed. Now it's up to Maki and Reimi to don skin-tight battle armor, liberate a tank, and make sure that a certain slaver learns that when you play with fire, you're going to get your ass burned!

Vanquished Queens OVAs depict what happened to various characters who were absent in Queen's Blade: Rebellion and what happened to them after Queen's Blade: Utsukushiki Toushitachi.