For more than four hundred years, the Takamimi Shrine has stood in Tokyo, enshrining the local goddess: Elda, a magical elf summoned from another world. The immortal elf has been served for 15 generations by the family who summoned her in the Edo period. Now, after Koito Koganei turns 16 years old, this responsibility falls onto her. Serving as Elda's shrine maiden, Koito must balance her responsibilities with her daily school life. This proves to be difficult because Elda is a total social recluse who loves video games, collecting toys, and eating snacks. In an effort to get the lazy shut-in to experience more of the outside world, Koito juggles her time between indulging Elda's various hobbies and getting her to interact with the rest of humanity. Along the way, Koito learns more about the history of the area and what makes the goddess so loved and spoiled by the locals.

Ichirou Kuga has suddenly found himself taking on the responsibility of caring for his two younger siblings after their father's untimely death. To make ends meet, Ichirou rents out rooms in the apartment complex he inherited and works full-time as a shoujo manga artist. However, his manga sales are low, his assistants have recently left, and deadlines are fast approaching. As stress threatens to overtake Ichirou, salvation comes in the form of an extremely competent novice artist, Shiori Goshiki, who becomes his new assistant. With her skills, they are able to tide over the difficult situation, and things begin looking up. But in a bizarre accident, a supernatural experience unfolds between Ichirou and Shirou, which leads her to declare them engaged. With this seemingly innocuous action upending his life, Ichirou now has to manage his new and peculiar relationship with the mysterious girl, all the while following his own passion and fulfilling the duties that rest on his shoulders.

Manji is an infamous swordsman in feudal Japan who is known as the "Hundred Man Killer," as he has killed one hundred innocent men. However, there is something far more frightening than his ominous reputation: the fact that he is immortal. This is the handiwork of eight-hundred-year-old nun Yaobikuni, who placed bloodworms capable of healing almost any wound in Manji's body. To atone for his crimes, Manji resolves to kill one thousand evil men. Yaobikuni agrees to this proposal, saying that if he succeeds, she will undo his curse of immortality. Soon after this promise, Manji meets Rin Asano, a 16-year-old girl who requests Manji's assistance in killing those who slaughtered her parents. Initially reluctant, Manji refuses Rin's desperate plea. However, owing to her evident lack of strength, Manji changes his mind and agrees to protect Rin for four years. With this partnership set in stone, the two embark on a perilous journey of bloodshed, vengeance, and redemption, each to fulfill their own life's cause.

In the beginning, God created the heavens and the earth. He also sought after a wide variety of animals to populate the planet. However, he felt that it was too tiresome to think of new ideas within his criteria. To address this problem, God appointed an organization—the Heaven's Design Team—to do the work instead! Shimoda is a newly-hired angel who serves as the mediator between God and the design team. As he steps into his role, he witnesses his coworkers conceive interesting ideas for many unique life forms according to God's desires. From giraffes and snakes to birds, anteaters, and everything in between, the possibilities for different animal species are endless!