The "Medicine Seller" is a deadly and mysterious master of the occult who travels across feudal Japan in search of malevolent spirits called "mononoke" to slay. When he locates one of these spirits, he cannot simply kill it; he must first learn its Form, its Truth, and its Reason in order to wield the mighty Exorcism Sword and fight against it. He must begin his strange exorcisms with intense psychological analysis and careful investigative work—an extremely dangerous step, as he must first confront and learn about the mononoke before he even has the means to defeat it. The Medicine Seller's journey leads him to an old-fashioned inn where Shino, a pregnant woman, has finally found a place to rest. The owner has reluctantly placed her in the last vacant room; however, as she settles in, it quickly becomes clear that the room is infested by a lethal band of mononoke, the Zashiki Warashi. With his hunter's intuition, the Medicine Seller begins his investigation to discover the Form, the Truth, and the Reason before the Zashiki Warashi can kill again. [Written by MAL Rewrite]

At the end of the first season, Doremi and her friends all had to give up their witch powers and be normal girls again. This also meant that they couldn't see Majorika, Lala, and the fairies again. The MAHO-Dou was also deserted and the door to the Majokai was locked. The Queen, having seen all this through her crystal ball, secretly makes it so that Doremi and co. all end up heading into the Majokai again, with the excuse to return Majorika's hair dryer. However they end up stumbling into a garden, and one of the roses reveals a baby! The Queen tells the girls that they must raise the baby for a whole year. To help them, they receive newer and stronger witch powers than before! The adventure isn't over yet!

After the losing of magical ability to become witches, they once again become them. But, now they have to go through tests from the Witches of the Witch World. They also meet a new member, from New York, U.S. comes Momoko (the yellow Ojamajo). (Source: ANN)

Na-i-sho is a 13 episode OAV series detailing the summer between the ~motto~ and the Dokkaan season. It is a bit more mature than the TV seasons, and looks to develop each of the five witches romantically. Hana is back to a baby, and the mahou shop is a bakery. (Source: ANN)