Miki Koishikawa is a high school student who enjoys a very simple life. However, her ordinary life is about to be turned upside down, and she may not be able to handle everything that is coming her way. After a very "fun" holiday in Hawaii, her parents have decided to get a divorce. As if this wasn’t enough of a shock for the poor girl, she also discovers that they will soon be re-marrying and swapping partners with another couple who they met on holiday. In order to include Miki in this shocking turn of events, they ask her to give the new couple a chance, and set up a dinner date with everyone. Miki may have tried to be emotionally prepared for her new parents, but what she was not expecting was their handsome son Matsuura Yuu. Miki develops an instant crush for Yuu. What starts off as a lovely friendship between them soon develops into romantic feelings which they are both finding hard to control. But more trouble is ahead in their relationship, as both Miki and Yuu have admirers of their own who are trying very hard to keep them separated.

The villainous Dr. Hell has amassed an army of mechanical beasts in his secret hideaway, the island of Bardos located in the Aegean Sea. He is capable of controlling mechanized beasts with his cane, and instructs them to unleash devastating attacks. However, Dr. Hell doesn't do all the dirty work by himself; he has his loyal henchman Baron Ashura to carry out his devilish plans. There are also those that will see to it that evil does not prevail. Kouji Kabuto is the young and feisty teenager with a score to settle: his goal is avenging the murder of his grandfather by Dr. Hell. And he might just be able to pull it off, as he is the pilot of Mazinger Z, a mighty giant robot made out of an indestructible metal known as Super-Alloy Z. Mazinger Z boasts several powerful special attacks. By channeling Photonic Energy through its eyes, and unleashing the Koushiryoku Beam, it can cause great destruction. But things get really cool when Mazinger Z launches its Rocket Punch attack. Dr. Hell and his minions might have just found their match!

The "Medicine Seller" is a deadly and mysterious master of the occult who travels across feudal Japan in search of malevolent spirits called "mononoke" to slay. When he locates one of these spirits, he cannot simply kill it; he must first learn its Form, its Truth, and its Reason in order to wield the mighty Exorcism Sword and fight against it. He must begin his strange exorcisms with intense psychological analysis and careful investigative work—an extremely dangerous step, as he must first confront and learn about the mononoke before he even has the means to defeat it. The Medicine Seller's journey leads him to an old-fashioned inn where Shino, a pregnant woman, has finally found a place to rest. The owner has reluctantly placed her in the last vacant room; however, as she settles in, it quickly becomes clear that the room is infested by a lethal band of mononoke, the Zashiki Warashi. With his hunter's intuition, the Medicine Seller begins his investigation to discover the Form, the Truth, and the Reason before the Zashiki Warashi can kill again. [Written by MAL Rewrite]

At the end of the first season, Doremi and her friends all had to give up their witch powers and be normal girls again. This also meant that they couldn't see Majorika, Lala, and the fairies again. The MAHO-Dou was also deserted and the door to the Majokai was locked. The Queen, having seen all this through her crystal ball, secretly makes it so that Doremi and co. all end up heading into the Majokai again, with the excuse to return Majorika's hair dryer. However they end up stumbling into a garden, and one of the roses reveals a baby! The Queen tells the girls that they must raise the baby for a whole year. To help them, they receive newer and stronger witch powers than before! The adventure isn't over yet!