Three hundred years ago, a genetic experiment gone wrong caused the mutation of all forests on Earth. Armed with consciousness, the vegetation sought to destroy all of humankind, and the war that ensued turned the planet into a hellish dystopia. In the present day, Agito, a young boy, lives with his father in Neutral City—a village maintaining an uneasy truce with the neighboring forest. One day, Agito, on his way to collect water, becomes separated from his friend and stumbles upon a relic of the past: a girl sleeping in a mysterious machine. Agito awakens the girl, Toola Cm Sacl, and introduces her to the village. But outside forces have ulterior motives for the girl, who holds the key to restore the Earth. Misguided by Shunack, a soldier from the old world hellbent on destroying the forest, Toola follows him despite Agito's warning. Determined to save Toola and unify humankind with the forest, Agito borrows the power of the forest and pursues her.

Susanoo, the youngest child of the creation gods Izanagi and Izanami, is a mighty warrior, easily able to defeat tigers with his bare hands. After his mother dies, Susanoo is devastated. Determined to travel to Heaven to find her, he carves a boat out of a tree, and along with his rabbit companion, Akahana, he prepares to cross the ocean. As Susanoo does not know how to reach Heaven, he first visits his brother, Tsukuyomi, leader of the Night Kingdom, and his sister, Amaterasu, leader of the Light Kingdom. While his siblings can warn Susanoo of the dangers he faces, they are unable to stop him or provide him with the directions to Heaven. As Susanoo continues his journey to the ends of the Earth, Orochi, an eight-headed dragon, awakens to stand in Susanoo's path.

One hundred years after their deaths at the hands of a former colleage, six legendary holy warriors are reborn to seek justice against the teammate who betrayed them into the hands of an evil god. Based upon one of the most popular video games of all time, Samurai Shodown is a sprawling feature-length saga of reincarnation and revenge, featuring some of the most spectacular battle sequences ever animated! Join Charlotte, Wan Fu, Nakoruru, Galford and Tamtam as they search the feudal province of Edo questing for their lost comrade, Haohmaru, and their sworn nemesis Shirou Amakusa. Will the followers of the divine light triumph over the forces of the dark, or is the course of history destined to repeat itself? Before their hundred-year journey has ended, six samurai will prove that the only thing stronger than their holy blades is the steel of their wills!