The red-light district, Yoshiwara, is suddenly taken over by "Aizen Kou," an incense that has the ability to make anyone fall in love with the first person they see. Having been outlawed for its strong potency, the love drug was thought to have disappeared from the red-light district for good; however, it seems to have found its way back inside Yoshiwara's walls and now has the entire district under its influence. Of those affected is the cold-hearted Hyakka captain, Tsukuyo, and the first person she sees after inhaling the smoke is none other than the brazen Yorozuya leader, Gintoki Sakata. Unbeknownst to everyone else though, she was already attracted to Gintoki. With those hidden feelings now intensified, Tsukuyo must overcome her afflictions and work with the Yorozuya to return everyone back to normal.

As Mikado Ryuugamine continues to purge the Dollars from within in accordance with his warped sense of justice, Masaomi Kida hopes to bring his friend back to his senses by bringing the Yellow Scarves together once more. Little do they know that a far more dominant force is about to enter their struggle for power, one that their friend Anri Sonohara is all too familiar with. Meanwhile, the group that has gathered at Shinra Kishitani's apartment realizes that they are on the brink of something life-changing, an event that will throw Ikebukuro into a spiral of confusion. Their anxiety is realized when reports of Celty's head being found in public start to appear all over the news as Kasane Kujiragi begins to make her move. Gone are the brief periods of tranquility as the current turmoil sets the stage for one final performance in this thrilling conclusion to the story of Ikebukuro's finest. [Written by MAL Rewrite]

Celty Sturluson is tasked to deliver a suspicious red handbag as part of her courier duties—the problem is: it is being sought by several organizations. As she makes her way through Ikebukuro toward the place the bag is supposed to be brought to, she is chased by mysterious men speaking a foreign language, and her package ends up dragging many of the city's residents into the conflict. Subsequently, famous actor Yuuhei Hanejima has just arrived in Ikebukuro as part of a special TV program, searching for the best couple to give them a chance to appear in one of his movies. However, Yuuhei Hanejima is actually a stage name for Kasuka Heiwajima, Shizuo's younger brother, and when an anonymous internet user threatens to kill the superstar, this user learns the weight of what that relationship means. Moreover, Shizuo discovers that the one responsible for the attempted attack is the meddlesome pest that he loathes with a burning passion. [Written by MAL Rewrite]

Keima Katsuragi, known online as the legendary "God of Conquest," can conquer any girl's heart—in dating sim games, at least. In reality, he opts for the two-dimensional world of gaming over real life because he is an unhealthily obsessed otaku of galge games (a type of Japanese video game centered on interactions with attractive girls). When he arrogantly accepts an anonymous offer to prove his supremacy at dating sim games, Keima is misled into aiding a naïve and impish demon from hell named Elucia "Elsie" de Lute Ima with her mission: retrieving runaway evil spirits who have escaped from hell and scattered themselves throughout the human world. Keima discovers that the only way to capture these spirits is to conquer what he hates the most: the unpredictable hearts of three-dimensional girls! Shackled to Elsie via a deadly collar, Keima now has his title of "God of Conquest" put to the ultimate test as he is forced to navigate through the hearts of a multitude of real-life girls. [Written by MAL Rewrite]