Shou and his friend, Tetsurou, stumble upon a strange orb-like mechanism, the Guyver Unit, in the woods. It physically bonds with Shou and turns him into the alien soldier, Guyver. His mission is to protect the Guyver Unit from the Japanese corporation known as Chronos. They are after it and two other units just like it. To retrieve the object, they send out vicious monsters known as Zoanoids. So no one is safe in Shou's life; not even himself.

At Maigahara Music College Affiliate School Maigahara Senior High (abbreviated as MaiMai) that gathers the most promising musical talents, there's a rumor circulating among students. "If you give an amazing performance at the school festival, you get special extra credit (or so they say)." Serina's grades are not very good, so she immediately believes the rumor and decides to form a band.

Minato visits a recitation at an anime event with his friend. He is captivated by the voice actors' performances and decides to enroll in Suidoubashi Animation Academy. There, he meets Chikako, who used to live in the room he is moving into and who left a message in a USB drive. Minato, who aims to be a voice actor but is unable to put himself into the role, and Chikako, who lives with a past trauma, encourage one another and try to improve themselves. With the help of seniors such as Ryouta and Kei watching over them, they try to mature. As they stumble and worry, what lies ahead for them both?

Rei goes to an anime convention and ends up in a world created by the desires of anime fans. Rei doesn't know how to get back and the world starts to collapse because the convention is coming to a close.