In Doumori, an imbalance of spiritual forces threatens to plunge the small city into complete chaos. Thankfully, for the students of Doumori Elementary School, new teacher and exorcist Meisuke "Nube" Nueno is determined to prevent the malignant spirits—known as youkai—from accomplishing their evil deeds. The first student who catches Nube's attention is transfer student Hiroshi Tateno, who displays inexplicable outbursts of anger, often lashing out at his classmates. When they find out that Hiroshi is possessed by a youkai, Nube manages to free his student thanks to the demonic power sealed in his left hand. However, a youkai hiding behind the appearance of doctor Kyousuke Tamano bursts onto the scene and quickly abducts Hiroshi. Helped by his student Kyouko Inaba and his expertise in the occult, Nube quickly uncovers Kyousuke's sinister plans. Rushing to Hiroshi's rescue, Nube will show once more that he will stop at nothing to protect his beloved students against all supernatural threats.

Panty and Stocking Anarchy, the angel twin sisters, have even more ghosts to exorcize in Daten City, thanks to the failed opening of the Hell Gate. They must continue their ghost hunt alongside their longtime rivals, the sisters Scanty and Kneesocks Demon, who must earn Hell Coins to return to Hell. On top of that, the Demon sisters are staying at the church with Garterbelt, the priest in charge of the Anarchy sisters. These two polar opposite duos will have to set aside their differences if they wish to collect enough Heaven and Hell Coins to complete their mission and return to their respective realms.

The qualities valued most in the study of magic are bloodline, aptitude, and effort. There was one sorcerer who, despite his deep love for magic, was born a commoner and thus lacked the bloodline and aptitude for it. As he died an unnatural death, he wished he had studied magic more while he had the chance. Then, he was reincarnated as Lloyd, the seventh prince of the Kingdom of Saloum and one blessed with a strong magical bloodline. Reborn with all his memories intact, along with the perfect bloodline and immense talent, he was determined to enjoy his new life, using his extraordinary magical abilities to master the study of magic that was beyond his reach in his previous life!

"Classes" are given at the age of 10, and the presence or absence of "skills" greatly affects life. Arel, the son of "Sword Princess" Fara and "Magic King" Leon, has been branded as "Classless"... But even without a job or skills, Arel believes he can persevere through effort.