This is the story of Puniru the slime and Kotarou, a middle school student, until they cease being friends... Kotarou Kawaii is a second-year middle school boy. When he was in elementary school, a slime he created came to life, and for the past seven years, he has been spending time with the slime named Puniru as his "friend." However, there is one problem for Kotarou... Over the seven years, both have grown significantly, and Puniru has transformed into an incredibly beautiful girl! Besides her beautiful appearance, Puniru freely transforms into various cute forms as a slime, causing Kotarou to be both excited and bewildered by her carefree behavior every time. Will Puniru and Kotarou be able to continue spending time together as "friends" despite these challenging days ahead?

"Hanako-san, Hanako-san... are you there?" At Kamome Academy, rumors abound about the school's Seven Mysteries, one of which is Hanako-san. Said to occupy the third stall of the third floor girls' bathroom in the old school building, Hanako-san grants any wish when summoned. Nene Yashiro, an occult-loving high school girl who dreams of romance, ventures into this haunted bathroom... but the Hanako-san she meets there is nothing like she imagined! Kamome Academy's Hanako-san... is a boy!

Nico Wakatsuki has finished her six years of witch training and is moving back to town by herself. As a new witch, she must choose a familiar to accompany her. However, unlike the other witches, she wishes to pick a non-animal familiar. There's no better companion than Morihito "Moi" Otogi—her childhood friend who happens to be an ogre. Morihito is vehemently opposed to being her servant, but he reluctantly accepts his fate after learning that a curse would revert him into a strange cow-tiger hybrid were he to disobey a witch's order. Due to Morihito's father leaving for a business trip and Nico's mother remaining behind in the Witches' Holy Land, the two teens find themselves living together under the same roof. While Nico is ecstatic to be living with her crush, Morihito finds that her magical antics and overall clumsiness create more problems than solutions. With a prophesied disaster to befall Nico within the year, Morihito must do everything he can to protect her as her bodyguard while also upholding his duties as her familiar.

In the not-too-distant future, the human world has long been overpopulated. Humanity marched to the stars in search of a new home, and just as this was going on, the moon's alignment caused massive earthquakes to ripple across the world, lasting several decades. Humanity was demolished. When the land finally recovered, humanity reemerged to face this strange yet familiar world. Will we, who once lorded over this domain, still remain the masters of this world?